The Santeros or Regla de Osha-Ifa is a set of religious systems that fuse Catholic beliefs with traditional Yoruba culture. It is, therefore, a religious belief arising from a syncretism of African and European elements. Santeria was practiced by the former black slaves and their descendants in Cuba, Puerto Rico, Dominican Republic, Panama, Venezuela, Brazil, Colombia and places with large Hispanic populations in the United States of America (Florida, New York, San Francisco, New Orleans , Los Angeles, Miami and San Diego). Today the religion has also presence in Spain, especially in the Canary Islands because of its close relationship with Cuba, Mexico, Netherlands, Germany, England, France and other countries where a considerable number of Cuban immigrants. In Venezuela, the Caracas region is where the highest concentration of Santeria and babalawos in the country but are also found in Cumana, Coro and Maracay. In Colombia, although it is well hidden, there is also presence of Santeria or the OSHA rule, especially in the city of Santiago de Cali and there are families formed by awos Santeria and babalawos Cubans, even today there are already stores items for Santeria. Santeria is the dean, heir and follower of the Yoruba culture has enriched all doctrines the precepts of the Yoruba diaspora is the legacy of the slaves who came from Nigeria and therefore the people of Ife, to Cuban soil. Just as the author has written the Prayer to St. Froilan, where exhibits and shows that the saint from the point of view of syncretism, could in a very certain syncretic mix with the Yoruba deity Osain, stressing throughout this study universality of the theology of Santeria, one of the heirs of the Yoruba culture, ie the Cuban Santeria.